Transgenic / Gene Targeted (Tg/GT) Animals

 

Purpose

Many Tg/GT animals are being constructed that require monitoring by the IACUC to comply with various federal regulations. When reviewing protocols, the IACUC has the responsibility to ensure the necessity for the use of live vertebrate animals and to ensure the appropriate use of species and strains for the proposed work.

Action

1. Any Tg/GT animal to be constructed and/or used at UConn Health must be named and described in an approved animal care and use protocol. This includes animals destined for use at either the UCHC or an outside institution.

2. All Tg/GT will be assigned a Genetically Modified Organism (GMO) number by the BSO or IACUC coordinator.  This GMO number must be reflected on the cage cards housing Tg/GT animals.

3. It is the responsibility of the PI to inform the IACUC if there are any phenotpyic pain or distress associated with the line, including unexpected lethality.  If this is not known at the time of initial use, it must be reported to the IACUC immediately upon discovery.

4.  Protocols must clearly indicate the recombinant lines to be used in that protocol.

 

Effective Dates:   August 25, 2022 through June 30, 2023

This policy has been approved by a majority vote of the IACUC members.