Purpose
In order to comply with federal regulations (USDA and PHS) and the Guide for the Care and Use of Laboratory Animals, UConn Health’s IACUC has established a policy on euthanasia of sick animals by CCM veterinary staff.
Action
- When sick animals are found by animal caretakers (ACT), a sick report is written up and an email is sent to the PI and/or contact individual identified on cage cards.
- The CCM Veterinary Services is also cc’d on the e-mail correspondence for their evaluation.
- If the animal is displaying signs of humane endpoints as identified in the animal care and use protocol or has a Body Condition Score (BCS) of 2 or less, veterinary staff will send an email to the PI and/or contact individual with recommendation of euthanasia. This may or may not be after consultation with the Attending Veterinarian. If the recommendation is for euthanasia of the animals, the email will include a due date and time for corrective action to the research staff. The PI must respond by email within 24 hours. If no response is received, this will be interpreted as consent by the PI to the medical opinion of the veterinary staff as to the disposition of the animal. The PI will be charged accordingly.
- If the veterinary staff identify the same animal during their routine veterinary clinical rounds, they will euthanize the animal and report it to PI and the IACUC.
- If the animal is moribund or in severe distress, the Veterinary Services can euthanize the animal immediately and notify the PI/research staff. If the animals are under Death as an Endpoint or EAE studies, they should be posted in the room or identified at cage level to avoid confusion.
Effective Dates: January 31, 2025 through December 31, 2027
This policy has been approved by a majority vote of the UConn Health IACUC
Statement of Compliance
The University of Connecticut (UConn) Health Center Institutional Review Boards (UConn Health IRBs) are organized and operate in accordance with applicable laws, regulations, and guidelines in the United States including, but not limited to, U.S. Food and Drug Administration (FDA) 21 CFR Parts 50 and 56, U.S. Department of Health and Human Services regulations 45 CFR Part 46, International Conference on Harmonisation (ICH) Good Clinical Practice (GCP), and the Belmont Report. Where appropriate, UConn Health IRBs comply with additional regulations and guidelines as required in specific research jurisdictions.
UConn Health IRBs are registered with FDA and OHRP and UConn Health Federalwide Assurance (FWA) is approved by OHRP:
- UConn Health IRB Panel 1 Registration #: IRB00000451
- UConn Health IRB Panel 2 Registration #: IRB00000452
- IRB Organization (IORG) #: IORG0000266
- FWA#: 00006064
The UConn Health Human Subjects Protection Program has been fully accredited by the Association for the Accreditation of Human Research Protection Programs (AAHRPP) since 2006.
The primary responsibility of UConn Health IRBs is to ensure that the rights and welfare of the human subjects who participate in research studies are protected.
Download the Compliance Statement
Federalwide Assurance
FWA#00006064, Expiration Date: March 10, 2030
Terms of the FWA
IRB Panel Information
IRB Registration Numbers
- UConn Health IRB Panel 1 Registration #: IRB00000451
- UConn Health IRB Panel 2 Registration #: IRB00000452
IRB Review Fees
QUICK TAKES
Welcome to the IACUC “Quick Takes” training page. These short (generally less than 5 minutes) videos are full of information for you as you work with laboratory animals here at UConn Health. This will be a library of videos – we will upload videos as we go along.
If you have an item you’d like to see as a Quick Take, or maybe you’d like to star in one, please email the IACUC office with your suggestion.
| Quick Takes |
| Welcome to Quick Takes from the IACUC Chair [featuring Dr. Stephen Crocker] (1:05) |
| An Animal Bit/Scratched Me – What Do I Do? [featuring Dr. Tim LeDean, Maria Clement, and Hunter Panier] – COMING SOON |
| Animal Safety Protocols (Biohazard, Chemical Hazard, or Combination) |
| Animal Protocols, Animal Safety Protocols, and IBC Registrations – a Primer (5:36) |
| Classification of Modifications of Protocols [featuring Mike Michaud] (3:57) |
| Classification of Surgical and Non-Surgical Procedures (4:22) |
| CMGM services (15:24) |
| CO2 Euthanasia of Laboratory Rodents (5:26) |
| Compassion Fatigue [featuring Dr. Jonathan Pohl and Richard Pohl] (13:04) |
| Continuing Problems – They Keep Popping Up (9:52) |
| Death as an Endpoint (3:25) |
| Expired Drug Training (6:04) |
| Drug Mixtures [featuring Carson Karanian and Crystol Vicente] (3:45) |
| Housing Animals in Containment Rooms – What You Need to Know – COMING SOON |
| Obtaining Research Controlled Substance Licenses [featuring Steve Jacobs] (3:20) |
| PAWS Review Notification – Am I In trouble? |
| Reporting Animal Welfare Concerns [featuring Dan Sasso] (4:19) |
| Reporting Unexpected Morbidity and/or Mortality [featuring Morgan LeDoyt] (4:39) |
| Sick Reports – What do I do? |
| Transportation of Laboratory Animals to PI Laboratories [featuring Robert Gottlieb] (3:07) |
| Use of Photography [featuring Joanne Walker] (8:05) |
| What Information Can You Find on the IACUC website? |
| What Information is Required on Cage Cards? [featuring Angela Thompson] (3:43) |
| 3R Search for Alternatives [featuring Marissa Iverson and Ryan Beach] (12:47) |
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| REUNITED SERIES |
| RRIT, RRCF, RNRIT – What are all of these forms? [featuring Drs. Jenna Bartley and Ron Wallace] (7:34) |
| Veterinary Consultation – What is required? [featuring Dr. Ramaswamy Chidambaram] (2:28) |
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| EVENTS |
| LAB FAMILY FEUD, JANUARY 28, 2025 |
| CONVERSATIONS WITH CCM, MARCH 18, 2025 |
| CONVERSATIONS WITH THE IACUC, JUNE 10, 2025 |
| JEOPARDY featuring Mike Centola (IO), Stephen Crocker (IACUC Chair), R. Chidambaram (AV) with host Tony Vella – to be held on October 28, 2025 – will be posted after that |
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| INFOED TRAINING SERIES |
| Overview |
| Section 1 |
| Section 2 |
| Section 3 |
| Section 4 |
| Section 5 |
| Section 6 |
| Section 7 |
| Section 8 |
| Section 9 |
| Section 10 |
| Section 11 |
| Section 12 |
| Section 13 |
| Section 14 |
| Modification |
| How to submit |
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| How to respond to review |
| Delegates |
Did you know that UConn Health is part of the ResearchMatch Network? ResearchMatch.org is a national online recruitment tool, funded by the National Institutes of Health and maintained at Vanderbilt University. ResearchMatch connects interested participants with health-related research studies that might be a good “match” for them through its secure, online matching tool. There is no cost to UConn Health researchers who use ResearchMatch to conduct recruitment feasibility analysis or participant recruitment.
For more information, including the process for using ResearchMatch as a recruitment tool, visit our ResearchMatch webpage or contact Ellen Ciesielski in Research Integrity & Compliance.
Environmental Health & Safety
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